Basic Information
VIS ID
TVIS44012830
Fusion event
HTLV-1-ABCA4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p22.1
Reference genome
GRCh37/hg19
Start
94523548/94057992 (Hg38)
End
94523548/94057992 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1D
Target gene
ABCA4
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-101-1/Upstream/211081; hsa-mir-11399/Downstream/485710;
Nearest TSS
ENST00000473358/Upstream/32397; ENST00000439455/Downstream/3447;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/148081, chr1-CpG: 93/Downstream/179142
Upstream sequence
GTGCTCTTCCCAGGAACATAAAGGAACAAATAGGTCCATGTCCTAAATGAGTTCTGATCAGTTGGCAGTAGTTCCCTGGAGCTCTGGCTTCCTCTCATAG
Downstream sequence
AAAAGAGACCAATGAGCTGTATCTGTGATGGGCATGCGAGAGCTGAGTGGAACGAATGTGCCATTTGTCTGCTGTGGCTGCCATTTCTCCTTTCTGCTCT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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