Basic Information
VIS ID
TVIS44012865
Fusion event
HTLV-1-PCSK2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr20
Cytoband
p12.1
Reference genome
GRCh37/hg19
Start
17261174/17280529 (Hg38)
End
17261174/17280529 (Hg38)
Orient
-
Location type
Intronic
Target gene
PCSK2
miRNAs that regulate target gene
hsa-mir-6848-3p ; hsa-mir-6843-3p ; hsa-mir-4666b ; hsa-mir-5011-3p ; hsa-mir-8052 ; hsa-mir-3199 ; hsa-mir-1288-3p ; hsa-mir-4518 ; hsa-mir-1266-5p ; hsa-mir-3664-3p ; hsa-mir-6754-5p ; hsa-mir-4441 ; hsa-mir-4270 ; hsa-mir-211-3p ; hsa-mir-522-3p ; hsa-mir-224-3p ; hsa-mir-4694-3p ; hsa-mir-335-3p ; hsa-mir-30e-3p ; hsa-mir-30d-3p ; hsa-mir-30a-3p ; hsa-mir-144-5p ; hsa-mir-4328 ; hsa-mir-500b-3p ; hsa-mir-660-5p
Nearest miRNA
hsa-mir-103a-2/Upstream/6630834; hsa-mir-1-1/Downstream/1190086;
Nearest TSS
ENST00000382410/Upstream/52398; ENST00000459871/Downstream/182904;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/51552, chr20-CpG: 31/Downstream/34951
Upstream sequence
GTCTTGTAATTATGCCTTATCCCAGAATGATGCCATGTGGAAGTTAGACACAGGCCCTTGTGTTTTAGAAAGTGTGGCAGAGCCTTCTCAACTTCAGAGT
Downstream sequence
CACCCAGAGGAAGTTATAAAAGTCAGAAGGGACCTATGGCTACATATAGTGGGCCATGTCTAATAAGAAGGTAGTTTTGTTCCAGAATTCTTTAGGTAGG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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