Basic Information
VIS ID
TVIS44012868
Fusion event
HTLV-1-VPS45 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
150062800/150090706 (Hg38)
End
150062800/150090706 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1F
Target gene
VPS45
miRNAs that regulate target gene
hsa-mir-15a-5p ; hsa-mir-16-5p ; hsa-mir-34a-5p ; hsa-mir-186-5p ; hsa-mir-100-5p ; hsa-mir-99a-5p ; hsa-mir-519e-5p ; hsa-mir-515-5p ; hsa-mir-5695 ; hsa-mir-519d-5p ; hsa-mir-186-3p ; hsa-mir-6782-3p ; hsa-mir-4429 ; hsa-mir-320d ; hsa-mir-320c ; hsa-mir-320b ; hsa-mir-320a
Nearest miRNA
hsa-mir-101-1/Upstream/1702343; hsa-mir-1182/Downstream/401639;
Nearest TSS
ENST00000473358/Upstream/12971; ENST00000472756/Downstream/1299;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/22948, chr1-CpG: 190/Downstream/58799
Upstream sequence
atactagcatggttaaatctccaccggcatttgcacctagaaatagagccagtccatcctctgcagccttattcctggggctcatgttttcttcaaatta
Downstream sequence
taaggtcttgaaaatactcacttctcataaagactactttgtcaaaattaaaaataccatatggagacagctttcttcatcaatcagtgtttgattgtta
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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