Basic Information
VIS ID
TVIS44012878
Fusion event
HTLV-1-CHMP2B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
87301320/87252170 (Hg38)
End
87301320/87252170 (Hg38)
Orient
-
Location type
Intronic
Target gene
CHMP2B
miRNAs that regulate target gene
hsa-mir-9-5p ; hsa-mir-124-3p ; hsa-mir-181a-5p ; hsa-mir-181b-5p ; hsa-mir-181c-5p ; hsa-mir-126-5p ; hsa-mir-493-5p ; hsa-mir-181d-5p ; hsa-mir-4262 ; hsa-mir-223-3p ; hsa-mir-4697-3p ; hsa-mir-16-1-3p ; hsa-mir-4698 ; hsa-mir-3924 ; hsa-mir-4795-3p ; hsa-mir-1256 ; hsa-mir-548o-3p ; hsa-mir-1323
Nearest miRNA
hsa-let-7g/Upstream/25893; hsa-mir-12124/Downstream/9107794;
Nearest TSS
ENST00000440867/Upstream/24861; ENST00000466696/Downstream/879;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/24734, chr3-CpG: 66/Downstream/540476
Upstream sequence
tatttagcttatgaaacatcttcagtttataccctagatgactgactaccttatgtgacatttccagggagtcatggctcatagattataggtttgttac
Downstream sequence
tatagcagtcctaaaccaggacaccctggtaggagcattgcatagacaaggactctcttgctagtaaatattaagcctatttgccaggagccccagttac
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate