Basic Information
VIS ID
TVIS44012900
Fusion event
HTLV-1-CLNK integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
p16.1
Reference genome
GRCh37/hg19
Start
10732888/10731264 (Hg38)
End
10732888/10731264 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA4A
Target gene
CLNK
miRNAs that regulate target gene
hsa-mir-4659b-3p ; hsa-mir-4659a-3p ; hsa-mir-6875-3p ; hsa-mir-4652-3p ; hsa-mir-629-3p ; hsa-mir-6867-3p ; hsa-mir-4713-5p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-3682-5p ; hsa-mir-3182 ; hsa-mir-942-5p ; hsa-mir-4685-3p ; hsa-mir-4287 ; hsa-mir-7113-3p ; hsa-mir-4469 ; hsa-mir-6832-3p ; hsa-mir-6768-5p ; hsa-mir-8485 ; hsa-mir-548x-3p ; hsa-mir-548j-3p ; hsa-mir-548aq-3p ; hsa-mir-548am-3p ; hsa-mir-548aj-3p ; hsa-mir-548ah-3p ; hsa-mir-548ae-3p ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac ; hsa-mir-1228-3p ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-377-3p ; hsa-mir-4279 ; hsa-mir-4722-3p ; hsa-mir-4740-3p ; hsa-mir-6727-3p ; hsa-mir-6747-3p ; hsa-mir-6778-3p
Nearest miRNA
hsa-mir-3138/Upstream/652572; hsa-mir-12113/Downstream/637563;
Nearest TSS
ENST00000502981/Upstream/46261; ENST00000635390/Downstream/6308;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/269199, chr4-CpG: 74/Downstream/637406
Nearby gene
CLNK(-46502) ;
Upstream sequence
ccatattccttctatgtaactgtttttttgtacccattaaccaacttctcCAGAAATTTGCACAATCATTATGTATTAGTTTTAGAAAAAGAATTATTTA
Downstream sequence
CTTCTCATCAACAAAAACTTCAAATGAACTATCAGATATTCTTTTTCTGAGACAGTCTCTCGCAATGCAACCACAGGGGATTTCTCCCCGGGTGGTTCGG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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