Basic Information
VIS ID
TVIS44012911
Fusion event
HTLV-1-chr10 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q26.11
Reference genome
GRCh37/hg19
Start
121374286/119614774 (Hg38)
End
121374286/119614774 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA10D ; FRA10F ; FRA10A ; FRA10B
Nearest miRNA
hsa-mir-107/Upstream/236731; hsa-mir-202/Downstream/343739;
Nearest TSS
ENST00000439456/Upstream/17745; ENST00000450186/Downstream/36596;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/17328, chr10-CpG: 134/Downstream/36280
Nearby gene
TIAL1(-17745) ;
Upstream sequence
CCTAGGCCCCGGACCCTGTAGCACACCTCTTTGTGGAAACTCAAAACCCGGCAGAGTTACCAGAGCTGTACCTGTGACCCAGTGCACCTCAGCTCCCAAC
Downstream sequence
CATCCAGTATACAGTCAGAATTTCAACTGGTCCCAGCAGCCGAAAGGAGTGGAAATGCAGAGCTAGCAACAGTTTACCTCCATAAATTCGACTCCCTGTT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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