Basic Information
VIS ID
TVIS44012918
Fusion event
HTLV-1-TMEM63C integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q24.3
Reference genome
GRCh37/hg19
Start
77707228/77240885 (Hg38)
End
77707228/77240885 (Hg38)
Orient
+
Location type
Intronic
Target gene
TMEM63C
miRNAs that regulate target gene
hsa-mir-4739 ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-185-3p ; hsa-mir-762 ; hsa-mir-5001-5p ; hsa-mir-4498 ; hsa-mir-6781-5p ; hsa-mir-4492 ; hsa-mir-6877-5p ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-5787 ; hsa-mir-765 ; hsa-mir-4505 ; hsa-mir-6081 ; hsa-mir-3192-5p ; hsa-mir-4508 ; hsa-mir-6784-5p ; hsa-mir-1225-3p ; hsa-mir-1233-3p ; hsa-mir-1236-5p ; hsa-mir-1245a ; hsa-mir-125a-5p ; hsa-mir-125b-5p ; hsa-mir-4319 ; hsa-mir-4765 ; hsa-mir-579-3p ; hsa-mir-664b-3p ; hsa-mir-6779-3p ; hsa-mir-7976 ; hsa-mir-8079
Nearest miRNA
hsa-mir-208a/Upstream/2760681; hsa-mir-1185-1/Downstream/25333;
Nearest TSS
ENST00000550708/Upstream/59058; ENST00000557504/Downstream/10824;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/58900, chr14-CpG: 116/Downstream/29505
Upstream sequence
CTGGGGCCCAGCTGCTCTCAAGGGGTGCCCAGGCCGGGGCTCCTCACTCCCTGTCCTTGCTTTAGCACAGAGGTGGTCAGAGAAGCCTTTGACCTCATGG
Downstream sequence
TCCCTCTTCTGCCCTTGACAAGAATGACATCCCTTTTCCCtttttctttttttttttttttctttttttttttttttctttttttgagagagtctcgctc
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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