Basic Information
VIS ID
TVIS44012940
Fusion event
HTLV-1-CA13 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
86176731/85264502 (Hg38)
End
86176731/85264502 (Hg38)
Orient
+
Location type
Intronic
Target gene
CA13
miRNAs that regulate target gene
hsa-mir-374b-5p ; hsa-mir-9-5p ; hsa-mir-192-5p ; hsa-mir-19b-3p ; hsa-mir-18a-5p
Nearest miRNA
hsa-mir-12123/Upstream/5023029; hsa-mir-10400/Downstream/5940983;
Nearest TSS
ENST00000518652/Upstream/14654; ENST00000520921/Downstream/72710;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/18563, chr8-CpG: 33/Downstream/174034
Upstream sequence
CTGCTCTTGTCATTGTTAGTCAGGAAATGTGAGTTTGCtttttttttgttttaattaaaatataaatGCTAATAGAAGTGGTATCAGTTCCTCTGTGAAG
Downstream sequence
GTATTGCTGCCAGTCTTAAGTAAGGTGTGTAGGAGAGAAAGAAAAATATTTTCTTGGCCTAGTTTCCCATCATAGTTTAAATAGTTGTACTTTTAACTAG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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