Basic Information
VIS ID
TVIS44012961
Fusion event
HTLV-1-ZNF436 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p36.12
Reference genome
GRCh37/hg19
Start
23694054/23367561 (Hg38)
End
23694054/23367561 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
ZNF436
miRNAs that regulate target gene
hsa-mir-7-5p ; hsa-mir-769-3p ; hsa-mir-320a ; hsa-mir-6124 ; hsa-mir-582-5p ; hsa-mir-7110-5p ; hsa-mir-6842-5p ; hsa-mir-6752-5p ; hsa-mir-4747-5p ; hsa-mir-5196-5p ; hsa-mir-4533 ; hsa-mir-1252-5p ; hsa-mir-6732-5p ; hsa-mir-9500 ; hsa-mir-5584-5p ; hsa-mir-4773 ; hsa-mir-651-3p ; hsa-mir-219a-1-3p ; hsa-mir-302a-5p ; hsa-mir-374b-3p ; hsa-mir-4476 ; hsa-mir-4524a-5p ; hsa-mir-4524b-5p ; hsa-mir-4690-5p ; hsa-mir-5191 ; hsa-mir-6077 ; hsa-mir-6165 ; hsa-mir-6510-5p ; hsa-mir-6876-5p ; hsa-mir-7641
Nearest miRNA
hsa-mir-12136/Upstream/323189; hsa-mir-101-1/Downstream/561509;
Nearest TSS
ENST00000473358/Upstream/23225; ENST00000518821/Downstream/825;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/22691, chr1-CpG: 106/Downstream/636
Upstream sequence
cttttcctggaatattcttctcacactagagaaattctactactctttaaggtcccgctgcagtactaactgttcttcaatgccccctacccctctgcac
Downstream sequence
ggctccactccccttggatgccccagatagacttaatcacgccgacttcttgggagtgattcccacactacagcactttgttcctacagcaagtagagca
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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