Basic Information
VIS ID
TVIS44012962
Fusion event
HTLV-1-ANO2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
p13.31
Reference genome
GRCh37/hg19
Start
5752962/5643796 (Hg38)
End
5752962/5643796 (Hg38)
Orient
-
Location type
Intronic
Target gene
ANO2
miRNAs that regulate target gene
hsa-mir-26b-5p
Nearest miRNA
hsa-mir-3649/Upstream/3983416; hsa-let-7i/Downstream/1319903;
Nearest TSS
ENST00000382841/Upstream/28501; ENST00000538418/Downstream/89384;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/148972, chr12-CpG: 17/Downstream/183914
Upstream sequence
ctatatcttttccaacacttgttactgacagacttttgggcatatatggtatctcattgtggtttaaattagaatttccaggattactaatgagattggg
Downstream sequence
taccattttataggctcattggccatttggattccctcttttgtgaagtacatattcatctttttcctattttgtactgaattactgttttccatgtttt
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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