Basic Information
VIS ID
TVIS44012965
Fusion event
HTLV-1-PPM1M integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p21.2
Reference genome
GRCh37/hg19
Start
52283342/52249326 (Hg38)
End
52283342/52249326 (Hg38)
Orient
+
Location type
Intronic
Target gene
PPM1M
miRNAs that regulate target gene
hsa-mir-744-5p
Nearest miRNA
hsa-mir-12127/Upstream/1574163; hsa-let-7g/Downstream/18952;
Nearest TSS
ENST00000440867/Upstream/365; ENST00000473583/Downstream/18812;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/3202, chr3-CpG: 97/Downstream/28727
Upstream sequence
CATGGCAACTGATGGACTCTGGGATGTACTGTCCAACGAGCAGGTGGCATGGCTGGTGCGGAGCTTCCTCCCTGGGAACCAAGAGGACCCACACAGGTAC
Downstream sequence
TGTAGCTGCTGGGGACCTGCCTGGGCCTGGGTTGGTGCCAGCAGCAAGCCCAAGTAGTTATGGCTGAGAAGACAGAGCACTGACAATGAGCTGGCAGCTG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate