Basic Information
VIS ID
TVIS44013004
Fusion event
HTLV-1-ADAMTS17 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q26.3
Reference genome
GRCh37/hg19
Start
100736156/100195951 (Hg38)
End
100736156/100195951 (Hg38)
Orient
-
Location type
Intronic
Target gene
ADAMTS17
miRNAs that regulate target gene
hsa-mir-7-5p ; hsa-mir-6805-3p ; hsa-mir-5691 ; hsa-mir-5571-3p ; hsa-mir-6502-5p ; hsa-mir-1301-5p ; hsa-mir-661 ; hsa-mir-139-5p ; hsa-mir-939-3p ; hsa-mir-3142 ; hsa-mir-1245b-5p ; hsa-mir-5683 ; hsa-mir-6510-3p ; hsa-mir-6888-3p ; hsa-mir-4522 ; hsa-mir-3120-5p ; hsa-mir-372-5p ; hsa-mir-371a-5p ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-371b-5p ; hsa-mir-3613-3p ; hsa-mir-3664-5p ; hsa-mir-2355-5p ; hsa-mir-432-5p ; hsa-mir-6793-3p ; hsa-mir-1912 ; hsa-mir-1295b-5p ; hsa-mir-6875-3p ; hsa-mir-3656 ; hsa-mir-3621 ; hsa-mir-543 ; hsa-mir-196a-3p ; hsa-mir-4419a ; hsa-mir-4510 ; hsa-mir-6127 ; hsa-mir-6129 ; hsa-mir-6130 ; hsa-mir-6133 ; hsa-mir-6760-5p ; hsa-mir-6873-5p
Nearest miRNA
hsa-mir-10393/Upstream/1411449; hsa-mir-1302-10/Downstream/1764508;
Nearest TSS
ENST00000557528/Upstream/69845; ENST00000560718/Downstream/65554;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/198290, chr15-CpG: 36/Downstream/96069
Upstream sequence
TTTAATGGGCCTATTGCAGCATGTATAATCATATAAGTGATCCCAAATCATATTAAGTAGTAACTATAAATTTTTAAAAAAGCAATACTagtttcctaac
Downstream sequence
ctgtaaagtaaaacctatataatgcctacctcataggactgactcaatggcgtgataaacacacagcatctcacacagtaccctgcacatagtaggtgtt
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate