Basic Information
VIS ID
TVIS44013007
Fusion event
HTLV-1-ZG16 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
29784397/29773076 (Hg38)
End
29784397/29773076 (Hg38)
Orient
+
Location type
Intronic
Target gene
ZG16
miRNAs that regulate target gene
hsa-mir-4659b-3p ; hsa-mir-4659a-3p ; hsa-mir-6875-3p ; hsa-mir-6809-3p ; hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-4753-3p ; hsa-mir-6881-3p ; hsa-mir-6780a-3p ; hsa-mir-7111-3p ; hsa-mir-130b-5p ; hsa-mir-877-3p ; hsa-mir-3607-5p ; hsa-mir-96-3p ; hsa-mir-2681-3p
Nearest miRNA
hsa-mir-1225/Upstream/173811; hsa-mir-11401/Downstream/730843;
Nearest TSS
ENST00000527434/Upstream/27070; ENST00000400752/Downstream/5164;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/77939, chr16-CpG: 36/Downstream/11964
Nearby gene
ZG16(+5164) ;
Upstream sequence
tcctaggctcaagcaatcctctgacctcagtcctccaagcactgagactgcaggtgtgcaccactatgcccagcTAAttttttttttttttttgagacgg
Downstream sequence
agtctcgctctgtggcccaggctggactgcaatggtgtgatctctgctcactgcagcctctgcctcccgggttcaagcgattcttctgcctcagcctccc
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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