Basic Information
VIS ID
TVIS44013013
Fusion event
HTLV-1-TMX3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
66368349/68701112 (Hg38)
End
66368349/68701112 (Hg38)
Orient
-
Location type
Intronic
Target gene
TMX3
miRNAs that regulate target gene
hsa-mir-590-3p ; hsa-mir-375 ; hsa-mir-155-5p ; hsa-mir-93-5p ; hsa-mir-877-5p ; hsa-mir-30c-2-3p ; hsa-mir-106b-5p ; hsa-mir-20a-5p ; hsa-mir-3146 ; hsa-mir-3129-3p ; hsa-mir-5583-5p ; hsa-mir-497-3p ; hsa-mir-548ay-3p ; hsa-mir-548at-3p ; hsa-mir-548t-3p ; hsa-mir-548as-3p ; hsa-mir-548ap-3p ; hsa-mir-548aa ; hsa-mir-519d-3p ; hsa-mir-20b-5p ; hsa-mir-17-5p
Nearest miRNA
hsa-mir-1-2/Upstream/1619426; hsa-mir-548av/Downstream/4152209;
Nearest TSS
ENST00000575820/Upstream/689; ENST00000582077/Downstream/13331;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/1184376, chr18-CpG: 67/Downstream/13585
Upstream sequence
AACTAAAATTTTAAAAAGGAAAAATTGGGAAGCACAACAGAATACCTACAATTAAACAGAAGGAAACGAAAGGATGATTTACTTAACACAAAAAGTAAGA
Downstream sequence
GGCTAAGCAAACATTTTTAAAAAGTGGGGGAAGGAAAAAGGTCGACACAAAACCCAATATATAAATTGAAATTACTCAAATTTAAAAATTTGAGATGTTA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate