Basic Information
VIS ID
TVIS44013044
Fusion event
HTLV-1-DPYSL3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q32
Reference genome
GRCh37/hg19
Start
146868003/147488440 (Hg38)
End
146868003/147488440 (Hg38)
Orient
-
Location type
Intronic
Target gene
DPYSL3
miRNAs that regulate target gene
hsa-mir-197-3p ; hsa-mir-375 ; hsa-mir-26b-5p ; hsa-mir-423-3p ; hsa-mir-218-5p ; hsa-mir-3685 ; hsa-mir-155-3p ; hsa-mir-5581-5p ; hsa-mir-4297 ; hsa-mir-3667-3p ; hsa-mir-4738-5p ; hsa-mir-5586-5p
Nearest miRNA
hsa-mir-10397/Upstream/3808469; hsa-mir-103a-1/Downstream/1573873;
Nearest TSS
ENST00000502646/Upstream/34174; ENST00000627433/Downstream/21095;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/34065, chr5-CpG: 93/Downstream/20747
Upstream sequence
GCCCTCAAAGGAGACCCTCTAAAATAGCGATGAatgggctacagggtcatgtggacctggatgtgagtcctatctctgccacCATCCTTTGAATATTATC
Downstream sequence
TACCCTGATTTTAGCCAGTGCCTTAAAATCAGGCTGGCCCACCAGCAAGCCACAGCAGTCAATAAAAAATTATCATTaccagcctgggcaacatagggaa
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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