Basic Information
VIS ID
TVIS44013052
Fusion event
HTLV-1-HIPK2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q34
Reference genome
GRCh37/hg19
Start
139419488/139719689 (Hg38)
End
139419488/139719689 (Hg38)
Orient
+
Location type
Intronic
Target gene
HIPK2
miRNAs that regulate target gene
hsa-mir-27a-3p ; hsa-mir-181a-5p ; hsa-mir-760 ; hsa-mir-423-5p ; hsa-mir-296-3p ; hsa-mir-615-3p ; hsa-mir-18a-3p ; hsa-mir-149-5p ; hsa-mir-222-3p ; hsa-mir-183-5p ; hsa-mir-218-5p ; hsa-mir-141-3p ; hsa-mir-934
Nearest miRNA
hsa-mir-10399/Upstream/675532; hsa-mir-11400/Downstream/2754838;
Nearest TSS
ENST00000635602/Upstream/2676; ENST00000473948/Downstream/57362;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/2966, chr7-CpG: 163/Downstream/57421
Nearest cancer related gene
HIPK2(TSG, No orient, 0)
Upstream sequence
gcgcttccaaagctgaaccccttattttttcctaaaaatctagccatctcaccctctatcctaacatctccatgactgttctagtcacttggctccaaaa
Downstream sequence
ctatgaactatgatggttcttctttacattcatagacaagaaggtgctaagccttattaatttctccttccttcaaaacatctcttgcatccaattcttt
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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