Proximate region of VIS (GRCh38)VISEnhancerEnhancer/PromoterPromoterGene148391358148328999148344636148295180148297556148333617148335624148302201148304200148314617148315822148317979148319169148307502148308206148317511148317855148309033148309222148343269
Basic Information
VIS ID
TVIS44013071
Fusion event
HTLV-1-NBPF8 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
147815397/148343269 (Hg38)
End
147815397/148343269 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1F
Target gene
NBPF8
miRNAs that regulate target gene
hsa-mir-421 ; hsa-mir-505-3p ; hsa-mir-4716-5p ; hsa-mir-4709-5p ; hsa-mir-1273h-3p ; hsa-mir-4771 ; hsa-mir-3166 ; hsa-mir-499b-5p
Nearest miRNA
hsa-mir-101-1/Upstream/8715; hsa-mir-1182/Downstream/45013;
Nearest TSS
ENST00000473358/Upstream/14270; ENST00000322209/Downstream/15417;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/8223, chr1-CpG: 16/Downstream/10770
Upstream sequence
TTTATGACAGTCAGTAGTCAGACACTATGTGCAGAGATCCTCCAGATCCTGTTTGACCAGCATCTTTGGGAGGTTAAGAGCCCAGCCCTGTCAGAACCAC
Downstream sequence
TATTCATTATCATCGACCCTTTCACCAGAATGCACCTGTGTGTCGGCTACTGATTTTCTCACCTCCAGGCAACTCAGGCTGAGCTGGGAGCAGAAATCTT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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