Basic Information
VIS ID
TVIS44013077
Fusion event
HTLV-1-SLC22A15 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p13.1
Reference genome
GRCh37/hg19
Start
116582402/116039781 (Hg38)
End
116582402/116039781 (Hg38)
Orient
+
Location type
Intronic
Target gene
SLC22A15
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-101-1/Upstream/3157652; hsa-mir-1182/Downstream/520243;
Nearest TSS
ENST00000473358/Upstream/7104; ENST00000464946/Downstream/71974;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/62865, chr1-CpG: 27/Downstream/112262
Upstream sequence
catcactagagagagaatatatggtcaccttttttgtataatcctttctatgcttgcaaagtcttccagctatgcctgaattttctcttctttcagataa
Downstream sequence
atagtaattgttctttaaactttctttaaaccttttgtatttactctttaaaatattttgttgacttttttttatctcaagtttttcaaagctttAGGCT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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