Basic Information
VIS ID
TVIS44013085
Fusion event
HTLV-1-TBCK integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q24
Reference genome
GRCh37/hg19
Start
107184228/106263071 (Hg38)
End
107184228/106263071 (Hg38)
Orient
+
Location type
Intronic
Target gene
TBCK
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-337-3p ; hsa-mir-4789-5p ; hsa-mir-3941 ; hsa-mir-6740-5p ; hsa-mir-6729-3p ; hsa-mir-6780b-3p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-6741-5p ; hsa-mir-6736-5p ; hsa-mir-4701-3p ; hsa-mir-1262 ; hsa-mir-1284 ; hsa-mir-202-5p ; hsa-mir-4436b-5p ; hsa-mir-223-5p ; hsa-mir-297 ; hsa-mir-3924 ; hsa-mir-567 ; hsa-mir-574-5p ; hsa-mir-6867-5p
Nearest miRNA
hsa-mir-12113/Upstream/4932657; hsa-mir-1243/Downstream/3225627;
Nearest TSS
ENST00000502981/Upstream/11064; ENST00000510207/Downstream/34668;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/366459, chr4-CpG: 61/Downstream/772327
Upstream sequence
TTTGCAGACATTGGTGCCTGCATTAAAATATTTTCTTGTCAACATTCCTTTTCTTTTTGAAAAGTTCAAATCTCAGAGCATAAGACAAATGTAATACTCA
Downstream sequence
CATACAATTAACCTAGCTTTATTAATTATCCTCTAATGTTTTAATCAAAAATTGTTCACATAGGAAATTTCCCCATACCTACAATATTAACATTTTCCTT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate