Basic Information
VIS ID
TVIS44013107
Fusion event
HTLV-1-WSCD2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
108561645/108167868 (Hg38)
End
108561645/108167868 (Hg38)
Orient
+
Location type
Intronic
Target gene
WSCD2
miRNAs that regulate target gene
hsa-mir-4496 ; hsa-mir-4704-5p ; hsa-mir-603 ; hsa-mir-8485 ; hsa-mir-6818-3p ; hsa-mir-6873-3p ; hsa-mir-539-3p ; hsa-mir-485-3p ; hsa-mir-3941 ; hsa-mir-6755-3p ; hsa-mir-593-3p ; hsa-mir-6895-3p ; hsa-mir-570-3p ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-758-3p ; hsa-mir-3611 ; hsa-mir-367-5p ; hsa-mir-1267
Nearest miRNA
hsa-let-7i/Upstream/3576152; hsa-mir-1178/Downstream/467942;
Nearest TSS
ENST00000382841/Upstream/36087; ENST00000546811/Downstream/21478;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/38172, chr12-CpG: 66/Downstream/347057
Upstream sequence
tgattagaatacctgcttgtttctgaaccaatcgctgtggtaggagagagatatgggccatgttgatgggcttaggctaggcaggacctatttttggagg
Downstream sequence
tgagtgttgggtcaaccccatgcaagccccactgttggatgaaatgtggATTCTGGAGAGCATCAATGCTAGAAGAGGGTGAGGGGTAAAATGATCCTGG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate