Basic Information
VIS ID
TVIS44013131
Fusion event
HTLV-1-PTGES3L integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q21.31
Reference genome
GRCh37/hg19
Start
41132451/42980434 (Hg38)
End
41132451/42980434 (Hg38)
Orient
-
Location type
UTR5
Target gene
PTGES3L
miRNAs that regulate target gene
hsa-mir-1273e ; hsa-mir-7847-3p ; hsa-mir-6880-5p ; hsa-mir-6851-5p ; hsa-mir-3689d ; hsa-mir-4722-5p ; hsa-mir-6086 ; hsa-mir-377-5p ; hsa-mir-1827 ; hsa-mir-219b-3p ; hsa-mir-4649-3p ; hsa-mir-4768-3p ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p ; hsa-mir-1912 ; hsa-mir-1295b-5p ; hsa-mir-302f ; hsa-mir-6516-5p ; hsa-mir-455-3p ; hsa-mir-6499-3p ; hsa-mir-4695-3p ; hsa-mir-4330 ; hsa-mir-4756-3p ; hsa-mir-3919 ; hsa-mir-5000-5p ; hsa-mir-4496 ; hsa-mir-4511 ; hsa-mir-548s ; hsa-mir-3926 ; hsa-mir-4786-5p ; hsa-mir-3190-5p ; hsa-mir-6728-3p ; hsa-mir-6849-3p ; hsa-mir-6771-3p ; hsa-mir-548c-3p ; hsa-mir-1293 ; hsa-mir-3165 ; hsa-mir-363-5p ; hsa-mir-4433a-3p ; hsa-mir-4459 ; hsa-mir-4483 ; hsa-mir-6745 ; hsa-mir-6748-5p ; hsa-mir-6756-5p ; hsa-mir-6766-5p ; hsa-mir-6769a-5p ; hsa-mir-6769b-5p ; hsa-mir-8056
Nearest miRNA
hsa-mir-1180/Upstream/156491; hsa-mir-10226/Downstream/464372;
Nearest TSS
ENST00000595228/Upstream/1; ENST00000590836/Downstream/56;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/15900, chr17-CpG: 90/Downstream/11
Upstream sequence
cagggaatgacttttccccggtatcattcacctgtttctccgacgcttactgctcagtgtctgattcacaataggcgctcaataaaacattattgtcctg
Downstream sequence
aattaaATTCCCGGGGAAGGCGCGCCCTCGGGGACTTGGGTACTTCAGGCCCCGCCCACCACTCCCCTGGGGTTCCAGGCCACCGCGCCGTTGCCATGGC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate