Basic Information
VIS ID
TVIS44013135
Fusion event
HTLV-1-GRHL1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p25.1
Reference genome
GRCh37/hg19
Start
10095127/9954998 (Hg38)
End
10095127/9954998 (Hg38)
Orient
-
Location type
Exonic
Target gene
GRHL1
miRNAs that regulate target gene
hsa-mir-192-5p ; hsa-mir-125a-5p ; hsa-mir-99a-5p ; hsa-mir-99b-5p ; hsa-mir-100-5p ; hsa-mir-539-3p ; hsa-mir-485-3p ; hsa-mir-29a-5p ; hsa-mir-1-5p ; hsa-mir-200b-5p ; hsa-mir-200a-5p ; hsa-mir-1183
Nearest miRNA
hsa-mir-7158/Upstream/3304559; hsa-mir-10b/Downstream/237616;
Nearest TSS
ENST00000437798/Upstream/3216; ENST00000494520/Downstream/5966;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/2671, chr2-CpG: 355/Downstream/55567
Upstream sequence
TTTAATTTCTCTGAAGCAAACGGCCAGTGTTGGTTCTTCAGAATGAAGCACTTTATCCACAGCGGCGGTCCTACACTAGTGAGGATGAGGCCTGGAAATC
Downstream sequence
CTTCCTGGAAAACCCTCTCACTGCAGCGACCAAAGCGATGATGAGCATCAATGGAGATGAAGACAGCGCCGCTGCGCTGGGCCTGCTCTATGACTACTAC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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