Basic Information
VIS ID
TVIS44013153
Fusion event
HTLV-1-PRICKLE2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p14.1
Reference genome
GRCh37/hg19
Start
64096835/64111159 (Hg38)
End
64096835/64111159 (Hg38)
Orient
-
Location type
Intronic
Target gene
PRICKLE2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-21-5p ; hsa-mir-5089-3p ; hsa-mir-5093 ; hsa-mir-4468 ; hsa-mir-219a-2-3p ; hsa-mir-219b-3p ; hsa-mir-4680-5p ; hsa-mir-4680-3p ; hsa-mir-6826-5p ; hsa-mir-4496 ; hsa-mir-6838-5p ; hsa-mir-497-5p ; hsa-mir-424-5p ; hsa-mir-195-5p ; hsa-mir-16-5p ; hsa-mir-15b-5p ; hsa-mir-15a-5p ; hsa-mir-4703-5p ; hsa-mir-3942-5p ; hsa-mir-4724-5p ; hsa-mir-3646 ; hsa-mir-421 ; hsa-mir-505-3p ; hsa-mir-7159-5p ; hsa-mir-520h ; hsa-mir-520g-3p ; hsa-mir-4272 ; hsa-mir-6074 ; hsa-mir-5692c ; hsa-mir-5692b ; hsa-mir-5692a ; hsa-mir-548ah-5p ; hsa-mir-3609 ; hsa-mir-203a-3p ; hsa-mir-19a-3p ; hsa-mir-19b-3p
Nearest miRNA
hsa-let-7g/Upstream/3493289; hsa-mir-12124/Downstream/3114305;
Nearest TSS
ENST00000440867/Upstream/7689; ENST00000473434/Downstream/43877;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/87542, chr3-CpG: 24/Downstream/156698
Upstream sequence
ctttggagttcaccttccagttctgtcccttgaagctgtgccttctcaggcaggcctggactcttttgtgctcagttccctcatctgtgaaatgggaata
Downstream sequence
atcatacaacctaagggagaaggtattaaatgggttaaaacacaaagtacttagaacagtgctggtgcggggacaccaatgaaatgttcaatCTTCTTAC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate