Basic Information
VIS ID
TVIS44013155
Fusion event
HTLV-1-DNAJC13 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
132256473/132537629 (Hg38)
End
132256473/132537629 (Hg38)
Orient
+
Location type
Intronic
Target gene
DNAJC13
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-106b-5p
Nearest miRNA
hsa-let-7g/Upstream/551698; hsa-mir-1224/Downstream/1830175;
Nearest TSS
ENST00000440867/Upstream/9427; ENST00000249887/Downstream/59608;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/119854, chr3-CpG: 18/Downstream/122085
Upstream sequence
TGCTGGCATATATGGCATTTTCATGCAATAGAAACTGTTAGAATCAAGGGAGAAATATAAGACTAAAATATCAGTACCCTTTCACATAGCATTCTTGTTT
Downstream sequence
TAACCTATGACAGATGGATGTCCAGAGCCTTTTCTTTTTCAGAGTCCTTGGTTTAGCAACCCTTGTTCGTTTGGTGTTACTTGTTATAATAGCATTTCTT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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