Basic Information
VIS ID
TVIS44013158
Fusion event
HTLV-1-GRID2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q22.2
Reference genome
GRCh37/hg19
Start
94394578/93473427 (Hg38)
End
94394578/93473427 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA4E
Target gene
GRID2
miRNAs that regulate target gene
hsa-mir-3924 ; hsa-mir-190a-3p ; hsa-mir-5011-5p ; hsa-mir-448
Nearest miRNA
hsa-mir-12113/Upstream/6172844; hsa-mir-1243/Downstream/5523960;
Nearest TSS
ENST00000502981/Upstream/153641; ENST00000637838/Downstream/295803;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/1167571, chr4-CpG: 112/Downstream/354917
Upstream sequence
cTTTCAGCTTAACATTGTACCATACTTCATATTTGAACATTTCAACAATTAAAATCACATAAGTTTTAATAGACTTTAAAAATATTTATTTAGAAAAGTA
Downstream sequence
ATAGTCAATTAAAATAATGTAAAATTCAGCTTTACATTACTGTGTCCCACTAGATATTGAGAAGAAGCTTAAGTACATTCAAACAGTTGAAACTACTTGG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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