Basic Information
VIS ID
TVIS44013183
Fusion event
HTLV-1-PRSS55 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
p23.1
Reference genome
GRCh37/hg19
Start
10396778/10539268 (Hg38)
End
10396778/10539268 (Hg38)
Orient
+
Location type
Intronic
Target gene
PRSS55
Nearest miRNA
hsa-mir-124-1/Upstream/635796; hsa-mir-10400/Downstream/127710;
Nearest TSS
ENST00000518652/Upstream/9856; ENST00000519925/Downstream/8289;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/134556, chr8-CpG: 19/Downstream/73017
Upstream sequence
CAAGAGGGCTTCTCAGCGGTGATGAGAACAaagaattccctgttgttctaggaagttagtctcttagttctacgcaggccttcagtggattggacaaggc
Downstream sequence
ccacccacattatgatgggcaatctgttgattcaaaagttatcaatttaaatgtcaatctcatccaaagataccctcCAAGTTGACATATGAGATGAACC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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