Basic Information
VIS ID
TVIS44013189
Fusion event
HTLV-1-RGS3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q32
Reference genome
GRCh37/hg19
Start
116283032/113520752 (Hg38)
End
116283032/113520752 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA9E
Target gene
RGS3
miRNAs that regulate target gene
hsa-mir-126-3p ; hsa-mir-133a-3p ; hsa-mir-26b-5p ; hsa-mir-25-3p
Nearest miRNA
hsa-let-7a-1/Upstream/1588583; hsa-mir-12126/Downstream/688682;
Nearest TSS
ENST00000422679/Upstream/3384; ENST00000470775/Downstream/1504;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/56899, chr9-CpG: 18/Downstream/63368
Upstream sequence
TTGAGTCAGCGACACGTTTTGTGGGACCCTGAGGGTTTGCTTTGTGTTTCTGGCTAGTTTAGAGCCTTCTTTCCATTGCTCGGACTTTGAAGTCTTCTCA
Downstream sequence
GACAACCAATTCCTTGACTCCTTCTGAGCTCTTGAGTCATTTTCTTCACCTCATCTCTTAACattattattatcattattattattaattattattTTTG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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