Basic Information
VIS ID
TVIS44013193
Fusion event
HTLV-1-ARHGEF6 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
q26.3
Reference genome
GRCh37/hg19
Start
135752178/136670019 (Hg38)
End
135752178/136670019 (Hg38)
Orient
-
Location type
Intronic
Target gene
ARHGEF6
miRNAs that regulate target gene
hsa-mir-30c-5p ; hsa-mir-877-5p ; hsa-mir-8085 ; hsa-mir-6731-5p ; hsa-mir-4306 ; hsa-mir-4644 ; hsa-mir-185-5p ; hsa-mir-6133 ; hsa-mir-6130 ; hsa-mir-6129 ; hsa-mir-6127 ; hsa-mir-4510 ; hsa-mir-4419a ; hsa-mir-1253 ; hsa-mir-6760-5p ; hsa-mir-6873-5p ; hsa-mir-6856-5p ; hsa-mir-6758-5p ; hsa-mir-5197-3p ; hsa-mir-888-5p ; hsa-mir-371a-5p
Nearest miRNA
hsa-let-7f-2/Upstream/119059; hsa-mir-105-1/Downstream/1997692;
Nearest TSS
ENST00000429181/Upstream/21792; ENST00000478471/Downstream/97324;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/172079, chrX-CpG: 104/Downstream/96852
Upstream sequence
gtggttaccataatcaagctaattaacatatccatctcctcacatagttaccttttgtatgtgtgtggtggaaatctacactcttagcaaacttcaagta
Downstream sequence
tactccattgtaaactatgcagtcTTCCCtccctcggtatccatggggtattggttcaaggacccccatggataccaaaatccacagatgctcaagtcct
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate