Basic Information
VIS ID
TVIS44013196
Fusion event
HTLV-1-TMX4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr20
Cytoband
p12.3
Reference genome
GRCh37/hg19
Start
7967328/7986681 (Hg38)
End
7967328/7986681 (Hg38)
Orient
+
Location type
Intronic
Target gene
TMX4
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-21-5p ; hsa-mir-324-3p ; hsa-mir-197-3p ; hsa-mir-20a-5p ; hsa-mir-190a-3p ; hsa-mir-6878-3p ; hsa-mir-6809-3p ; hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-642a-5p ; hsa-mir-4778-3p ; hsa-mir-6778-3p ; hsa-mir-4469 ; hsa-mir-877-3p ; hsa-mir-2276-5p ; hsa-mir-6892-3p ; hsa-mir-6849-3p ; hsa-mir-8055 ; hsa-mir-8081 ; hsa-mir-627-5p ; hsa-mir-937-5p ; hsa-mir-3682-5p ; hsa-mir-924 ; hsa-mir-500a-5p
Nearest miRNA
hsa-mir-103a-2/Upstream/614989; hsa-mir-1-1/Downstream/2662955;
Nearest TSS
ENST00000382410/Upstream/46207; ENST00000607924/Downstream/27249;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/1216371, chr20-CpG: 96/Downstream/32461
Upstream sequence
TTAGGGTTTAAAATGCAATCAAACTAATCAAGATTAGGTTAAGAGAAATAAAAAATAACAAGAAGTACAACATGCTGAACATTTATAGTTGCCTATGTAG
Downstream sequence
TTAGATAAATAAATTTATTATTCAACTCTTGCCTGAAATACCTGGGGAGAAAATACCTGGGGAGATATATACTGCATACTGATTTTCATGCCCAAAGAAT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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