Basic Information
VIS ID
TVIS44013212
Fusion event
HTLV-1-COL26A1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
101115739/101472458 (Hg38)
End
101115739/101472458 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA7F
Target gene
COL26A1
Nearest miRNA
hsa-mir-10525/Upstream/312903; hsa-mir-10399/Downstream/820645;
Nearest TSS
ENST00000635602/Upstream/109581; ENST00000613091/Downstream/80745;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/108296, chr7-CpG: 31/Downstream/215904
Upstream sequence
tcaggacatctctttaagttcgaggtcttatttagttagttaactcatcccttccaccataaacaccctgtaaccaagagtgcctaacttcctgggaatg
Downstream sequence
taacctaccaggtttggctttatttggccattattcaagatggagtcactctggttgagactcctccaacaGGTGGATCCATTCCGCCATGGAGGGGTTG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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