Basic Information
VIS ID
TVIS44013213
Fusion event
HTLV-1-ACTR3C integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q36.1
Reference genome
GRCh37/hg19
Start
149583444/149886355 (Hg38)
End
149583444/149886355 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA7I
Target gene
ACTR3C
miRNAs that regulate target gene
hsa-mir-379-3p ; hsa-mir-487a-3p ; hsa-mir-127-3p ; hsa-mir-539-3p
Nearest miRNA
hsa-mir-10399/Upstream/2508234; hsa-mir-153-2/Downstream/1352066;
Nearest TSS
ENST00000635602/Upstream/4775; ENST00000609463/Downstream/4384;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/12055, chr7-CpG: 189/Downstream/160958
Nearby gene
ATP6V0E2(+5643) ;
Upstream sequence
TATGTGAGACAGGACCTGACAAATAAGTACTATGAAAAATACCTGGGGCCTGCTTATGTATCTGCATTTTTGTGTTTCCTGTCGAATGTCTTTAATGTAT
Downstream sequence
AAATGTAGCATCTTCTCAGTAAAAACACAAATGCTTTTGGAGGACGGGGGGAGGAAGCAGATACTAGaattggcatgctgtttctaaagccctctgggaa
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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