Basic Information
VIS ID
TVIS44013222
Fusion event
HTLV-1-RPS6KC1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q32.3
Reference genome
GRCh37/hg19
Start
213276752/213103410 (Hg38)
End
213276752/213103410 (Hg38)
Orient
-
Location type
Intronic
Target gene
RPS6KC1
miRNAs that regulate target gene
hsa-mir-26b-5p
Nearest miRNA
hsa-mir-101-1/Upstream/1025725; hsa-mir-1182/Downstream/7014443;
Nearest TSS
ENST00000473358/Upstream/30472; ENST00000468069/Downstream/26117;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/51885, chr1-CpG: 19/Downstream/285986
Upstream sequence
TCTGTATTTTAGTCAGTATGATAGAACTTGAAGATTCAaagaaccatgatattctattaagtgcttactatgtgcctcgcatgaaactgggaaccttaag
Downstream sequence
tacattatccatttcctacattttaaaaatgaggaaataatctgcctaagattttatagctagtgaatgatagaggtagtatttgaattcaggtcCTTTT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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