Basic Information
VIS ID
TVIS44013228
Fusion event
HTLV-1-TPCN1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q24.13
Reference genome
GRCh37/hg19
Start
113677420/113239615 (Hg38)
End
113677420/113239615 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA12E ; FRA12D
Target gene
TPCN1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-23b-3p
Nearest miRNA
hsa-let-7i/Upstream/80438; hsa-mir-1178/Downstream/51908;
Nearest TSS
ENST00000382841/Upstream/14369; ENST00000552542/Downstream/4646;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/17763, chr12-CpG: 34/Downstream/95213
Upstream sequence
TAGAAGTTGCATATCTGGGAGTGAGTCACCGGTTTCCAAAAACATCCAGGGTCCCAGGTGACTGTCACAGCTAAACCAGCCCCTGGAGCCACTGGAGGGT
Downstream sequence
GACAAGGAGACTCATTCACATGTGATCAGACCAGAAGTAGCCCAGCAGGGCATGGCGTTGCTGCCCCTAGGAACAGCCTACTTTTTGGATGTTTGGGTCT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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