Basic Information
VIS ID
TVIS44013236
Fusion event
HTLV-1-ZNF174 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
3456594/3406594 (Hg38)
End
3456594/3406594 (Hg38)
Orient
+
Location type
Intronic
Target gene
ZNF174
miRNAs that regulate target gene
hsa-mir-877-5p ; hsa-mir-92a-3p ; hsa-mir-372-5p ; hsa-mir-371a-5p ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-371b-5p ; hsa-mir-6747-3p ; hsa-mir-6752-3p ; hsa-mir-520h ; hsa-mir-520g-3p ; hsa-mir-3159 ; hsa-mir-3973 ; hsa-mir-6877-3p ; hsa-mir-6819-3p ; hsa-mir-520e ; hsa-mir-520d-3p ; hsa-mir-520c-3p ; hsa-mir-520b ; hsa-mir-520a-3p ; hsa-mir-373-3p ; hsa-mir-372-3p ; hsa-mir-302e ; hsa-mir-302d-3p ; hsa-mir-302c-3p ; hsa-mir-302b-3p ; hsa-mir-302a-3p ; hsa-mir-93-5p ; hsa-mir-526b-3p ; hsa-mir-519d-3p ; hsa-mir-20b-5p ; hsa-mir-20a-5p ; hsa-mir-17-5p ; hsa-mir-106b-5p ; hsa-mir-106a-5p
Nearest miRNA
hsa-mir-1225/Upstream/874589; hsa-mir-11401/Downstream/78787;
Nearest TSS
ENST00000527434/Upstream/4620; ENST00000573617/Downstream/36948;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/4927, chr16-CpG: 41/Downstream/36504
Upstream sequence
ttgatttgaggttttgatttacatttccctagtgactaatggtgttgaacatcttttcatgtgcttattatccagttacatatcttgtgtggaaaaatat
Downstream sequence
ctgttcagatcctttggtcatttttaaattaggttatttgtctttattttttataagagtcctttatgtattctagatactagacccttatgtgtaattt
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate