Basic Information
VIS ID
TVIS44013237
Fusion event
HTLV-1-ASPSCR1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q25.3
Reference genome
GRCh37/hg19
Start
79945298/81987422 (Hg38)
End
79945298/81987422 (Hg38)
Orient
+
Location type
Intronic
Target gene
ASPSCR1
miRNAs that regulate target gene
hsa-let-7b-5p
Nearest miRNA
hsa-mir-10226/Upstream/293553; hsa-mir-4525/Downstream/249246;
Nearest TSS
ENST00000595228/Upstream/9236; ENST00000582355/Downstream/8021;
Nearest CpG islands
chr17-CpG: 53/Target, None/Upstream, None/Downstream
Nearest cancer related gene
ASPSCR1(OG, No orient, 0)
Upstream sequence
CGGCGCCCTGGCTCTGTGCTGCTTCCTGAGACGAGAGTGGCAGAGGGCAAGAAGAAAACCAAACAGCGCGGGGAACAGAAGTCAGGAAAGATGAACGTCT
Downstream sequence
GGAAGGAAATGCCCCTGGGCCGGGCGGTGCCCCCGGGCGTGAACAGAATCCAGTGCTCCCACAGGCACAGGTGCTTGGTGAGGGCCGTCCTCCCTGGCTG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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