Basic Information
VIS ID
TVIS44013254
Fusion event
HTLV-1-STX18 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
p16.3
Reference genome
GRCh37/hg19
Start
4454640/4452913 (Hg38)
End
4454640/4452913 (Hg38)
Orient
-
Location type
Intronic
Target gene
STX18
miRNAs that regulate target gene
hsa-mir-124-3p
Nearest miRNA
hsa-mir-4800/Upstream/2202757; hsa-mir-12113/Downstream/1470362;
Nearest TSS
ENST00000502981/Upstream/26300; ENST00000499430/Downstream/9024;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/64721, chr4-CpG: 72/Downstream/88797
Upstream sequence
ccattaagaacattcgtgattcatgggaggaggtcaaaatatcaactttaacaggagtttggaagaagtggattccaaccttcctgaataactttgaggg
Downstream sequence
gttcaagacttcagtggaggaagtcactggagatgtggtggaaacagccagagaactaagattggaagtggagactgaagatgcggctgagctgctgcaa
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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