Basic Information
VIS ID
TVIS44013269
Fusion event
HTLV-1-ACOT13 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p22.3
Reference genome
GRCh37/hg19
Start
24695329/24695101 (Hg38)
End
24695329/24695101 (Hg38)
Orient
-
Location type
Intronic
Target gene
ACOT13
miRNAs that regulate target gene
hsa-mir-548s ; hsa-mir-3926 ; hsa-mir-4786-5p ; hsa-mir-3190-5p ; hsa-mir-6849-3p ; hsa-mir-10b-5p ; hsa-mir-10a-5p ; hsa-mir-6732-3p
Nearest miRNA
hsa-mir-3691/Upstream/6123221; hsa-mir-10398/Downstream/2452525;
Nearest TSS
ENST00000381078/Upstream/7699; ENST00000606921/Downstream/6692;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/27934, chr6-CpG: 94/Downstream/25269
Upstream sequence
AAACTGTGCCTTAAAATACACTTAAACTGAggcgcggtggctcatgcctgtaatcccagcattttgggaggccgaggtgggtggatcacctgaggtcaag
Downstream sequence
agttcaagaccaacctggctaacatggcaaaaccccatctctactaaaaatacaaaaattagccaggcatggtggcacgcacctgtagtcccatctactc
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate