Basic Information
VIS ID
TVIS44013270
Fusion event
HTLV-1-NFKBIL1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p21.33
Reference genome
GRCh37/hg19
Start
31525646/31557869 (Hg38)
End
31525646/31557869 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA6H
Target gene
NFKBIL1
miRNAs that regulate target gene
hsa-mir-93-3p
Nearest miRNA
hsa-mir-3143/Upstream/202553; hsa-mir-10398/Downstream/75918;
Nearest TSS
ENST00000381078/Upstream/9442; ENST00000454783/Downstream/14185;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/15750, chr6-CpG: 80/Downstream/22790
Upstream sequence
CTCCAAGGAGCGGGAATGGAGACAGAAGCTCCAGGGTGAGCTGGAGGACGAGTGGCAGGAAGTCATGGGGAGGTTTGAAGGTGAGAAGTCCACTGCTATC
Downstream sequence
CACAGCTGCCCTTCCCCACTGGCTGCTTTCCATCTGCATGAATGCGTCACACTAGGCTCCTCTGCCCCCTCCTCTGTGCTTCCCTGCTTCTTGGGGCCCA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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