Basic Information
VIS ID
TVIS44013271
Fusion event
HTLV-1-BRPF3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p21.31
Reference genome
GRCh37/hg19
Start
36168014/36200237 (Hg38)
End
36168014/36200237 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA6H
Target gene
BRPF3
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-1-3p ; hsa-mir-877-3p ; hsa-let-7b-5p ; hsa-mir-545-3p ; hsa-mir-885-3p ; hsa-mir-1204 ; hsa-mir-4776-3p ; hsa-mir-4659b-5p ; hsa-mir-5590-5p ; hsa-mir-4659a-5p ; hsa-mir-6861-3p ; hsa-mir-6821-3p ; hsa-mir-6840-3p ; hsa-mir-7856-5p ; hsa-mir-1185-2-3p ; hsa-mir-1185-1-3p ; hsa-let-7f-2-3p ; hsa-mir-4789-5p ; hsa-mir-98-3p ; hsa-let-7f-1-3p ; hsa-let-7b-3p ; hsa-let-7a-3p ; hsa-mir-8063 ; hsa-mir-501-5p ; hsa-mir-4666a-3p ; hsa-mir-381-3p ; hsa-mir-300 ; hsa-mir-6771-3p ; hsa-mir-4668-3p ; hsa-mir-548as-3p
Nearest miRNA
hsa-mir-1236/Upstream/535448; hsa-mir-10398/Downstream/422199;
Nearest TSS
ENST00000381078/Upstream/2785; ENST00000527657/Downstream/60;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/2809, chr6-CpG: 61/Downstream/187263
Upstream sequence
ctcaaaggaagtgaaggagcaagccatgtggatgcctgaggggcaagttgttcagacagagggaaaagccagtCCTCTTGGTGGATGCTTGATCATATGG
Downstream sequence
GAGGATGAATGGGTGCATAAGGGCATCCAACTCATAGTCTCCTGGCCTTCTCTCCTTAGGCCTGTCCCCTCAGTTCCCAGGTGCCATGAGGAAGCCTCGT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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