Basic Information
VIS ID
TVIS44013286
Fusion event
HTLV-1-MEI1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
42176952/41780948 (Hg38)
End
42176952/41780948 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA22A
Target gene
MEI1
miRNAs that regulate target gene
hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-6818-3p ; hsa-mir-4314 ; hsa-mir-6873-3p ; hsa-mir-4436b-5p ; hsa-mir-2861 ; hsa-mir-378g ; hsa-mir-4486 ; hsa-mir-6860 ; hsa-mir-612 ; hsa-mir-5189-5p ; hsa-mir-3187-5p ; hsa-mir-1285-3p ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-6845-3p ; hsa-mir-3925-3p ; hsa-mir-766-3p ; hsa-mir-6758-3p
Nearest miRNA
hsa-mir-1281/Upstream/527898; hsa-let-7a-3/Downstream/119996;
Nearest TSS
ENST00000624155/Upstream/4837; ENST00000484966/Downstream/403;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/80763, chr22-CpG: 76/Downstream/19001
Upstream sequence
tgttgggattacaggcgtaagccactgcggaggcctgagctgaatcttgattgctgacggggacaagaggagttagctaaatgaagtgatgtgagagagg
Downstream sequence
ggatgtggcaagtgcagggaactgcaCTTCATTCGACTGTTAAAGTTCCCTTGGGAAGGTGGTGACGATGTTCACAGGATGGATCCCTTTGAAATCCTAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate