Basic Information
VIS ID
TVIS44013287
Fusion event
HTLV-1-GTF2E1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q13.33
Reference genome
GRCh37/hg19
Start
120487776/120768929 (Hg38)
End
120487776/120768929 (Hg38)
Orient
+
Location type
Intronic
Target gene
GTF2E1
miRNAs that regulate target gene
hsa-mir-361-5p ; hsa-mir-221-3p ; hsa-mir-24-3p ; hsa-let-7f-5p ; hsa-mir-561-3p ; hsa-mir-8061 ; hsa-mir-4760-5p ; hsa-mir-137 ; hsa-mir-92b-3p ; hsa-mir-92a-3p ; hsa-mir-367-3p ; hsa-mir-363-3p ; hsa-mir-32-5p ; hsa-mir-25-3p ; hsa-mir-506-3p ; hsa-mir-124-3p ; hsa-mir-550a-3p ; hsa-mir-200c-5p ; hsa-mir-31-5p ; hsa-mir-3910 ; hsa-mir-3714 ; hsa-mir-548c-3p
Nearest miRNA
hsa-let-7g/Upstream/373200; hsa-mir-12124/Downstream/280711;
Nearest TSS
ENST00000440867/Upstream/25936; ENST00000495504/Downstream/67431;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/172286, chr3-CpG: 62/Downstream/139104
Upstream sequence
AGCCAAGGTTGCTTCTTACCCTTTGTTACCAAATATAAAAGCTAGTTTTCAACTCTTGTTGGCCTCTTAATATTAGGACCATACATTTCCTTGAAACACC
Downstream sequence
ATCCTGTCACTCTGGTTGCACCATTTCTCTTTCTCAAGGATTCCTCATTccttgagtttatgccttaactgcttcttctcactctccttaatctcttcgg
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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