Basic Information
VIS ID
TVIS44013293
Fusion event
HTLV-1-ALPK2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
q21.32
Reference genome
GRCh37/hg19
Start
56273592/58606360 (Hg38)
End
56273592/58606360 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA18B
Target gene
ALPK2
miRNAs that regulate target gene
hsa-mir-214-3p
Nearest miRNA
hsa-mir-1-2/Upstream/155202; hsa-mir-5011/Downstream/8475224;
Nearest TSS
ENST00000575820/Upstream/25387; ENST00000622763/Downstream/22597;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/349524, chr18-CpG: 92/Downstream/64619
Upstream sequence
gtagagatgaagtctcactgtgttgcccaggcttgtctcaaactcctggcctcaagcaatcctcctgcctcaccctcccaaagtgctgagattgcaggca
Downstream sequence
tgagccaccaccatgctcagccTGTTACTTTAAACAAAGGACTAGATAGGAGATAAGAAAGCTTTTGTGTTTATGAACAACTCCTCTACAATGAAACTTC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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