Basic Information
VIS ID
TVIS44013308
Fusion event
HTLV-1-KLF5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
73631991/73057853 (Hg38)
End
73631991/73057853 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA13B
Target gene
KLF5
miRNAs that regulate target gene
hsa-mir-145-5p ; hsa-mir-141-3p ; hsa-mir-9-5p ; hsa-mir-128-3p ; hsa-mir-21-5p ; hsa-mir-143-3p ; hsa-mir-4480 ; hsa-mir-489-3p ; hsa-mir-4668-3p ; hsa-mir-153-3p
Nearest miRNA
hsa-mir-1297/Upstream/6839529; hsa-mir-1267/Downstream/4640159;
Nearest TSS
ENST00000623511/Upstream/2877; ENST00000476859/Downstream/939;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/275379, chr13-CpG: 163/Downstream/869
Nearest cancer related gene
KLF5(OG, No orient, 0)
Upstream sequence
GTGTGTCAACATATGTACATTTGTAGTAATATCACAGGCATTTTTATTGCAGTTTATTGTTCCGTCCTCCCAATAAGCCAGATAAAATCATGTACAAGAA
Downstream sequence
CATTAAGGATTAAGGGAAGTGGTTTCCTTAGGTGATTGCTGGCAAAAATTCACCCTCCCATTATAACAACATAGTAAATGGATGGTAATATATTTGGCTA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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