Basic Information
VIS ID
TVIS44013323
Fusion event
HTLV-1-ACTR3B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q36.1
Reference genome
GRCh37/hg19
Start
152476111/152779026 (Hg38)
End
152476111/152779026 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA7I
Target gene
ACTR3B
miRNAs that regulate target gene
hsa-mir-379-3p ; hsa-mir-487a-3p ; hsa-mir-539-3p ; hsa-mir-127-3p ; hsa-mir-4524b-5p ; hsa-mir-4524a-5p ; hsa-mir-4710 ; hsa-mir-8085 ; hsa-mir-6731-5p ; hsa-mir-6797-5p ; hsa-mir-1249-5p ; hsa-mir-765 ; hsa-mir-621 ; hsa-mir-4660 ; hsa-mir-6804-5p ; hsa-mir-6133 ; hsa-mir-6130 ; hsa-mir-6129 ; hsa-mir-6127 ; hsa-mir-4510 ; hsa-mir-4419a ; hsa-mir-5690 ; hsa-mir-6760-5p ; hsa-mir-4779 ; hsa-mir-646 ; hsa-mir-503-5p ; hsa-mir-6838-5p ; hsa-mir-497-5p ; hsa-mir-424-5p ; hsa-mir-195-5p ; hsa-mir-16-5p ; hsa-mir-15b-5p ; hsa-mir-15a-5p
Nearest miRNA
hsa-mir-10399/Upstream/1345387; hsa-mir-153-2/Downstream/4795310;
Nearest TSS
ENST00000635602/Upstream/19238; ENST00000488782/Downstream/21597;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/18600, chr7-CpG: 21/Downstream/114949
Upstream sequence
agtgagactgtgtctccaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaGGACATATGAGTTATTTCTTCTGAACTTCTGACCAGTATTA
Downstream sequence
AACTTCAGTATTATAGACATATCGTGCTAAATGTGGTGGGTGGAAGAAGGTTGTGGTATAATGTGACAGTGAGGAAGCTTGCATTATATAAAAATGCTAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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