Basic Information
VIS ID
TVIS44013332
Fusion event
HTLV-1-ST18 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q11.23
Reference genome
GRCh37/hg19
Start
53189008/52276448 (Hg38)
End
53189008/52276448 (Hg38)
Orient
+
Location type
Intronic
Target gene
ST18
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-580-3p ; hsa-mir-451b ; hsa-mir-1255a ; hsa-mir-1255b-5p ; hsa-mir-3691-5p ; hsa-mir-376b-5p ; hsa-mir-376c-5p ; hsa-mir-3911 ; hsa-mir-4711-3p ; hsa-mir-4752 ; hsa-mir-496 ; hsa-mir-574-5p ; hsa-mir-627-5p ; hsa-mir-6744-5p ; hsa-mir-6818-5p ; hsa-mir-6867-5p ; hsa-mir-8056 ; hsa-mir-924
Nearest miRNA
hsa-mir-124-1/Upstream/9380173; hsa-mir-10400/Downstream/9438340;
Nearest TSS
ENST00000518652/Upstream/22100; ENST00000522228/Downstream/18007;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/376696, chr8-CpG: 117/Downstream/288536
Upstream sequence
atgcacaccacacacacacgccacatactacacatacaccatacgttcacatacacacaccacacccacacaccacacacaacacatgcacacCAAACAC
Downstream sequence
AAGATGACCTCTATGAAACCAAAAAAAGGAAAGTTATTTTCCCAGTTCTTTTAGGAAAATTATGCTGGACATTCCAGGAGCCTATGTTGTGTGGCAGGAG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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