Basic Information
VIS ID
TVIS44013346
Fusion event
HTLV-1-MAP4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p21.31
Reference genome
GRCh37/hg19
Start
47968807/47927317 (Hg38)
End
47968807/47927317 (Hg38)
Orient
-
Location type
Intronic
Target gene
MAP4
miRNAs that regulate target gene
hsa-mir-34a-5p ; hsa-mir-103a-3p ; hsa-mir-16-5p ; hsa-mir-551b-3p ; hsa-mir-484 ; hsa-mir-339-5p ; hsa-mir-331-3p ; hsa-mir-328-3p ; hsa-mir-23b-3p ; hsa-mir-196a-5p ; hsa-mir-100-5p ; hsa-mir-92a-3p ; hsa-let-7b-5p ; hsa-mir-1207-5p ; hsa-mir-1827 ; hsa-mir-1913 ; hsa-mir-2682-5p ; hsa-mir-3151-5p ; hsa-mir-324-3p ; hsa-mir-34b-5p ; hsa-mir-34c-5p ; hsa-mir-4421 ; hsa-mir-4446-3p ; hsa-mir-4447 ; hsa-mir-4472 ; hsa-mir-449a ; hsa-mir-449b-5p ; hsa-mir-449c-5p ; hsa-mir-4720-3p ; hsa-mir-4763-3p ; hsa-mir-486-3p ; hsa-mir-491-5p ; hsa-mir-5587-3p ; hsa-mir-5693 ; hsa-mir-5699-3p ; hsa-mir-6132 ; hsa-mir-6721-5p ; hsa-mir-6742-5p ; hsa-mir-6748-3p ; hsa-mir-6762-3p ; hsa-mir-6773-3p ; hsa-mir-6796-3p ; hsa-mir-6796-5p ; hsa-mir-6829-5p ; hsa-mir-6836-5p ; hsa-mir-6860 ; hsa-mir-6879-3p ; hsa-mir-6882-3p ; hsa-mir-99a-3p ; hsa-mir-99b-3p
Nearest miRNA
hsa-mir-12127/Upstream/77688; hsa-let-7g/Downstream/269247;
Nearest TSS
ENST00000440867/Upstream/16929; ENST00000296435/Downstream/985;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/77263, chr3-CpG: 98/Downstream/161118
Upstream sequence
ATTACTTTGTACCTAGGAAAGCCGATAACTGACAAATGGTACAGAACATCACATACTAGGTTATTTGAAACAAACGATGAGCATCTTATAAGTTAGATGT
Downstream sequence
CAAAAAAGAAGCCATATTTAAGTGGAAACATAACTTGAGCTCTCAATCTGGCTAACAGGGAAGTACCAAAGCTATTCCTTTAAGGCTCTTTTGGAACTCA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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