Basic Information
VIS ID
TVIS44013370
Fusion event
HTLV-1-C2orf49 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q12.2
Reference genome
GRCh37/hg19
Start
105976261/105359804 (Hg38)
End
105976261/105359804 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
C2orf49
miRNAs that regulate target gene
hsa-mir-192-5p ; hsa-mir-190a-3p ; hsa-mir-5011-5p ; hsa-mir-1277-5p ; hsa-mir-6806-3p ; hsa-mir-3928-5p ; hsa-mir-600 ; hsa-mir-5580-3p ; hsa-mir-6796-3p ; hsa-mir-5089-5p ; hsa-mir-548s ; hsa-mir-6807-5p ; hsa-mir-3926 ; hsa-mir-5589-5p ; hsa-mir-4731-5p ; hsa-mir-6720-3p ; hsa-mir-668-5p ; hsa-mir-4252 ; hsa-mir-6506-5p ; hsa-mir-619-5p ; hsa-mir-3190-5p ; hsa-mir-1273g-3p ; hsa-mir-1295b-3p ; hsa-mir-3186-5p
Nearest miRNA
hsa-mir-1285-2/Upstream/2927438; hsa-mir-10b/Downstream/3781686;
Nearest TSS
ENST00000437798/Upstream/22272; ENST00000415627/Downstream/3234;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/22012, chr2-CpG: 96/Downstream/38617
Nearby gene
FHL2(-1022) ;
Upstream sequence
TAATGACTGTGTGTCTCTCCTGCTTTACTGCCCTTTTCAGAAACACTGAAGGCTCCCAGTGTGCCCTCAGTTGCGAGggtgttgagaacataaagatgaa
Downstream sequence
caggatgtcgtctctggcctcaagttgcttatgtccttgtgCAATCTTTCACTTTATGGAAGTCGGTGTAAGATGTGGATCCATAACACTGGGACAGAGC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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