Basic Information
VIS ID
TVIS44013372
Fusion event
HTLV-1-NGLY1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p24.2
Reference genome
GRCh37/hg19
Start
25826454/25784963 (Hg38)
End
25826454/25784963 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA3A
Target gene
NGLY1
miRNAs that regulate target gene
hsa-mir-186-5p
Nearest miRNA
hsa-mir-12127/Upstream/120024; hsa-let-7g/Downstream/5376741;
Nearest TSS
ENST00000440867/Upstream/807; ENST00000428266/Downstream/5076;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/998, chr3-CpG: 26/Downstream/4902
Upstream sequence
gagtaatttctttctggctcatataacactttaatAATGCAGGTGTCATAATGTCAGTGGACCCAGTCTCCTTCCATACCTTAGAAcaggggtcaagaaa
Downstream sequence
cattttctgtaaagggccacatagtgttttaggctttgtgagccataaggtctgtctcaactatttaactctgcctctgcagctgttgctccacagacaa
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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