Basic Information
VIS ID
TVIS44013397
Fusion event
HTLV-1-SUFU integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q24.32
Reference genome
GRCh37/hg19
Start
104374909/102615152 (Hg38)
End
104374909/102615152 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
SUFU
miRNAs that regulate target gene
hsa-mir-378a-3p ; hsa-mir-378a-5p ; hsa-mir-93-3p ; hsa-mir-214-3p ; hsa-mir-181a-2-3p ; hsa-mir-3914 ; hsa-mir-4252 ; hsa-mir-6719-3p ; hsa-mir-6788-3p ; hsa-mir-6840-3p ; hsa-mir-873-5p ; hsa-mir-888-3p
Nearest miRNA
hsa-mir-107/Upstream/178568; hsa-mir-1307/Downstream/779101;
Nearest TSS
ENST00000439456/Upstream/24343; ENST00000646349/Downstream/27158;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/110754, chr10-CpG: 321/Downstream/26912
Nearest cancer related gene
SUFU(TSG, No orient, 0)
Upstream sequence
tcttgggggcattgtgaggagtagccagtcagtgagaagtgcttggtgcagtggctggcgctcgccaggcatatacagaatgatggctGTCACCATCATT
Downstream sequence
ATCATCAGTCACCATTATTGTCTTTATTACTCAGGAGCCCAGCTGGAGACTCCCATCTTGCTCCTCCCTGAGCTTTTCACCTTGTGCCGAACCTTTTCCT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate