Basic Information
VIS ID
TVIS44013403
Fusion event
HTLV-1-DIS3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q21.33
Reference genome
GRCh37/hg19
Start
73346326/72772188 (Hg38)
End
73346326/72772188 (Hg38)
Orient
-
Location type
Exonic
Fragile sites / regions
FRA13B
Target gene
DIS3
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-26b-5p ; hsa-mir-30c-5p ; hsa-mir-6749-3p ; hsa-mir-150-5p ; hsa-mir-186-3p ; hsa-mir-4698 ; hsa-mir-3146 ; hsa-mir-129-5p ; hsa-mir-450a-5p ; hsa-mir-8082 ; hsa-mir-4534 ; hsa-mir-6514-5p ; hsa-mir-4765 ; hsa-mir-640 ; hsa-mir-8079 ; hsa-mir-1245a ; hsa-mir-802
Nearest miRNA
hsa-mir-1297/Upstream/6553864; hsa-mir-1267/Downstream/4925824;
Nearest TSS
ENST00000623511/Upstream/44260; ENST00000489797/Downstream/9666;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/44172, chr13-CpG: 80/Downstream/9377
Nearest cancer related gene
DIS3(OG, No orient, 0)
Upstream sequence
TTCTAGTTCAAAAGAAAATGAACTCAGAACAGAACTATATTTAGGTAAGAACACTATTACATATGAATACCTCCAAATTTCCATTTTCGAGTTCTCGACA
Downstream sequence
ATGTAGAGCATCGTCTATATCAGTACATCCTGGTGGGTCTACACTACAAATACACAGATGCCTCAGGTCTTCTCGGTTTTTCATGTCCTAGAAGACATGA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate